Out in California's San Fernando Valley, Isabel is trying to reinvent herself. A naïve, good-natured witch, she is determined to disavow her supernatural powers and lead a "normal" life. At the same time--across town--Jack Wyatt, a tall, charming actor is trying to get his career back on track. He sets his sights on an updated version of the beloved 1960's situation comedy "Bewitched," reconceived as a starring vehicle for himself in the role of the mere-mortal Darrin. Fate steps in when Jack accidentally runs into Isabel. He is immediately attracted to her and her nose, which bears an uncanny resemblance to the nose of Elizabeth Montgomery, who played Samantha in the original TV version of "Bewitched." He becomes convinced she could play the witch, Samantha, in his new series. Isabel is also taken with Jack, seeing him as the quintessential mortal man, with whom she can settle down and lead the normal life she so desires. It turns out they're both right--but in ways neither of them ever imagined.
Nicole Kidman, Will Ferrell, Shirley MacLaine, Michael Caine, Jason Schwartzman, Kristin Chenoweth, Heather Burns, Jim Turner, Stephen Colbert, David Alan Grier, Michael Badalucco, Carole Shelley, Steve Carell, Katie Finneran, James Lipton, Conan O'Brien, Amy Sedaris, Richard Kind, Ken Hudson Campbell, P.J. Byne, Carol Androsky, Annie Mumolo, Andrew Friedman, Clay Bravo, Heather Freedman, Jonathan Floyd, Ed McMahon, Bridget Brno, Dana Daurey, Dorie Barton, Jennifer Elise Cox, Laura Sorenson, Brittany Paige Bouck, Jennifer Hall, Roxanne Beckford, J.J. Sacha, Susan Chuang, Jordan Black, Mo Rocca, Wendi McLendon-Covey, Jason George, Julie Claire, Dianne Dreyer, Kate Walsh, Valerie Azlynn, Jarrad Paul, Victor L Williams, Molly Gordon, Nick Lachey