After falling into a coma following a freak accident, cartoonist Stu Miley becomes trapped in the fantasy land of his own imagination. In this land called Downtown, nestled somewhere between life and death, he must somehow find the means to return to reality. In order to escape Downtown, Stu must outwit Death herself... but the cartoonist's own comic creation, Monkeybone, has come to life, and is intent on wreaking havoc on Stu's plans.