Paul Harris is a scientist at a small research facility on the outskirts of Boston. After a weekend tryst with his attractive and promiscuous co-worker Danielle leaves him wanting more, his unreciprocated desires gradually mold into an acute infatuation over the following months. When Danielle takes interest in a new researcher at the laboratory, Paul's suppressed resentments and perverse delusions finally become unhinged, triggering a horrific course of events that mercilessly engulf a tortured past and fugitive present.